G6PD Deficiency drugs, medicine to avoid

Contraindicated vs Allergy.

G6PD Deficiency does not cause individuals to be allergic to the substances below as commonly believed. An allergy causes itchy eyes, runny nose, etc. whereas in a person with G6PD Deficiency these substances cause red blood cells to burst (hemolysis) and can lead to hemolytic anemia.

G6PD Deficiency Drugs to Avoid and Other Contraindicated Substances

Low Risk drugs, medicine, foods and other substances below MAY be safe at normal theraputic doses. People with Class 1 G6PD Deficiency (ie: Mediterranean variant among others) may still react to low risk substances. Consult with your physician before using any of these substances.

We try our best to keep this list up to date, but the constant influx of new drugs, medicines and research makes this task quite difficult. To be safe the following classes of drugs, medicines and other substances should be avoided if at all possible.

NSAIDS (Asprin, Ibuprophen)

Tylenol

Quinolones

Drugs metabolized through the liver or known to cause blood or liver related problems or hemolysis

Sulfa drugs

Petrochemically derived substances (This is a long list and gets longer every year. Many artificial foods, dyes and vitamins are included in this list.)

Moth Balls and anything containing naphthalene.

Artificial Food Coloring (Methylene and Toluidine blue)

When in doubt, the safest course of action is to avoid the substance. If you react to something not on this list, avoid that substance in the future. Watch carefully for hemolysis signs at all times.

To learn more about a substance (including information links, synonyms, notes, etc), click on the substance name. To just see a list of synonyms, click on the Synonym link.

Acetaminophen	Analgesics / Antipyretics
C₈H₉NO₂	Low Risk - Synonyms
N-(4-hydroxyphenyl)acetamide

Acetanilid	Analgesics
C₈H₉NO	High Risk - Synonyms
N-phenylacetamide

Acetylphenylhydrazine	Antimicrobial
C₈H₁₀N₂O	High Risk - Synonyms
1-Acetyl-2-phenylhydrazine, Acetylphenylhydrazine

Aminophenazone	Analgesics
C₁₃H₁₇N₃O	Low Risk - Synonyms
4-dimethylamino-1,5-dimethyl-2-phenyl-pyrazol-3-one

Antazoline	Antihistamine
C₁₇H₁₉N₃	Low Risk - Synonyms
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline

Antipyrine	Analgesics / Antipyretics
C₁₁H₁₂N₂O	Low Risk - Synonyms
2,3-DIMETHYL-1-PHENYL-3-PYRAZOLIN-5-ONE

Ascorbic Acid	Vitamin
C₆H₈O₆	Low Risk - Synonyms
(R)-3,4-dihydroxy-5-((S)- 1,2-dihydroxyethyl)furan-2(5H)-one

Aspirin	Anti Inflammatory
C₉H₈O₄	High Risk - Synonyms
2-acetyloxybenzoic acid

Astemizole	Antihistamine
C₂₈H₃₁FN₄O	Low Risk - Synonyms
1-[(4-fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4 -piperidyl]-benzoimidazol-2-amine

Beta-Naphthol	Miscellaneous
C₁₀H₈O	High Risk - Synonyms
2-Naphthol

Chloramphenicol	Antibacterial
C₁₁H₁₂C₁₂N₂O₅	High Risk - Synonyms
2,2-dichloro-N-[1,3-dihydroxy-1-(4-nitrophenyl)-propan-2-yl] -acetamide

Chloroquine	Antimalarials
C₁₈H₂₆ClN₃	High Risk - Synonyms
N'-(7-chloroquinolin-4-yl)-N,N-diethyl-pentane-1,4-diamine

Ciprofloxacin	Quinolones
C₁₇H₁₈FN₃O₃	High Risk - Synonyms
1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-ca rboxylic acid

Colchicine	Anti Inflammatory
C₂₂H₂₅NO₆	Low Risk - Synonyms
(S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a ] heptalen-7-yl) acetamide

Dapsone	Sulfones
C₁₂H₁₂N₂O₂S	High Risk - Synonyms
4-(4-aminophenyl)sulfonylaniline

Dimercaprol	Miscellaneous
C₃H₈OS₂	High Risk - Synonyms
2,3-Dimercaptopropanol

Diphenhydramine	Antihistamine
C₁₇H₂₁NO	Low Risk - Synonyms
2-benzhydryloxy-N,N-dimethyl-ethanamine

Dopamine	Anti-epileptic
C₈H₁₁NO₂	Low Risk - Synonyms
4-(2-aminoethyl)benzene-1,2-diol

Doxorubicin	Chemotherapeutic
C₂₇H₂₉NO₁₁	High Risk - Synonyms
10-(4-amino-5-hydroxy-6-methyl-oxan-2-yl)oxy-6,8,11-t rihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetr acene-5,12-dione

Furazolidone	Antibiotics
C₈H₇N₃O₅	High Risk - Synonyms
3-[(5-nitro-2-furyl)methylideneamino]oxazolidin-2-one

Furosemide	Diuretic
C₁₂H₁₁ClN₂O₅S	High Risk - Synonyms
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid

Glucosulfone	Miscellaneous
C₂₄H₃₄N₂Na₂O₁₈S₃	High Risk - Synonyms

Glyburide	Antidiabetic Agent
C₃₂H₂₈ClN₃O₅S	High Risk - Synonyms
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl] -2-methoxy-benzamide

Henna	Miscellaneous
C₁₀H₆O₃	High Risk - Synonyms
4-hydroxynaphthalene-1,2-dione

Ibuprofen	Analgesics / Antipyretics
C₁₃H₁₈O₂	Low Risk - Synonyms
2-[4-(2-methylpropyl)phenyl]propanoic acid

Isobutyl Nitrite	Miscellaneous
C₄H₉NO₂	High Risk - Synonyms
Nitrous acid, 2-methylpropyl ester

Isoniazid	Antibiotics
C₆H₇N₃O	Low Risk - Synonyms
pyridine-4-carbohydrazide

Lamotrigine	Antidepressants
C₉H₇Cl₂N₅	High Risk - Synonyms
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine

Levofloxacin	Anti-bacterial
C₃₆H₄₂F₂N₆O₉	High Risk - Synonyms
(-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperaz inyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4 benzoxazine-6-carboxylic acid hemihydrate

Magnevist	Contrast Agent
C₂₈H₅₄GdN₅O₂₀	Low Risk - Synonyms
2-[bis[2-[carboxymethyl-(2-oxido-2-oxoethyl)amino]ethyl]amin o]acetate; gadolinium(+3) cation; (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol

Mefloquine	Anitmalarials
C₁₇H₁₆F₆N₂O	High Risk - Synonyms
[2,8-bis(trifluoromethyl)quinolin-4-yl]-piperidin-2-ylmethan ol

Menadiol Sodium Sulfate (Vitamin k4 sodium sulfate)	Miscellaneous
C₁₁H₈Na₂O₈S₂	High Risk - Synonyms

Menadione	Miscellaneous
C₁₁H₈O₂	High Risk - Synonyms
2-methylnaphthalene-1,4-dione

Menadione sodium Bisulfite (Vitamin K3 sodium bisulfite)	Miscellaneous
C₁₁H₈O₂NaHSO₃	High Risk - Synonyms

Menthol	Miscellaneous
C₁₀H₂₀O	High Risk - Synonyms
2-(2-Propyl)-5-methylcyclohexanol

Mesalazine	Anti Inflammatory
C₇H₇NO₃	High Risk - Synonyms
5-amino-2-hydroxy-benzoic acid

Methylene Blue	Miscellaneous
C₁₆H₁₈ClN₃S	High Risk - Synonyms
3,7-Bis(dimethylamino)phenazathionium chloride

Mirtazapine	Antidepressant
C₁₇H₁₉N₃	Low Risk - Synonyms
1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c ][2]benzazepine

Moxifloxacin	Anti-bacterial
C21H24FN3O4	High Risk - Synonyms
1-cyclopropyl-7-[(1S,6S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6- fluoro-8-methoxy-4-oxo-quinoline-3-carboxylic acid

Nalidixic Acid	Antibacterial
C₁₂H₁₂N₂O₃	High Risk - Synonyms
1-ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid

Naphthalene	Miscellaneous
C₁₀H₈	High Risk - Synonyms
Naphthalene

Nimesulide	Anti-Inflammatory Agents
C₁₃H₁₂N₂O₅S	High Risk - Synonyms
N-[4-nitro-2-(phenoxy)phenyl]methanesulfonamide

Niridazole	Miscellaneous
C₆H₆N₄O₃S	High Risk - Synonyms
1-(5-Nitro-2-thiazolyl)-2-imidazolinone

Nitrofurantoin	Cytotoxic / Antibacterial
C₈H₆N₄O₅	High Risk - Synonyms
1-[(5-nitro-2-furyl)methylideneamino]imidazolidine-2,4-dione

Nitrofurazone	Cytotoxic / Antibacterial
C₆H₆N₄O₄	High Risk - Synonyms
1-amino-N-[(5-nitro-2-furyl)methylideneamino]methanamide

Norfloxacin	Antibiotics
C₁₆H₁₈FN₃O₃	Low Risk - Synonyms
1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1H-quinoline-3-carbo xylic acid

Oxidase, Urate	Miscellaneous
C₁₅₂₁H₂₃₈₁N₄₁₇O₄₆₁S₇	High Risk - Synonyms
Aspergilus urate oxidase

Pamaquine	Antimalarials
C₄₂H₄₅N₃O₇	High Risk - Synonyms
N,N-diethyl-N'-(6-methoxyquinolin-8-yl)pentane-1,4-diamine

Para-Aminobenzoic Acid	Miscellaneous
C₇H₇NO₂	Low Risk - Synonyms
4-Aminobenzoic Acid

Pefloxacin	Anti-Infective
C₁₇H₂₀FN₃O₃	High Risk - Synonyms
1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline- 3-carboxylic acid

Pentaquine	Antimalarials
C₁₈H₂₇N₃O	High Risk - Synonyms
1,5-Pentanediamine, N-(6-methoxy-8-quinolinyl)-N'-(1-methylethyl)-

Phenacetin	Analgesics
C₁₀H₁₃NO₂	High Risk - Synonyms
N-(4-ethoxyphenyl)ethanamide

Phenazopyridine	Miscellaneous
C₁₁H₁₁N₅	High Risk - Synonyms
3-phenyldiazenylpyridine-2,6-diamine

Phenylbutazone	Anti-inflammatory
C₁₉H₂₀N₂O₂	Low Risk - Synonyms
4-butyl-1,2-diphenyl-pyrazolidine-3,5-dione

Phenylhydrazine	Miscellaneous
C₆H₈N₂	High Risk - Synonyms
Phenylhydrazine

Phenytoin	Anticonvulsants
C₁₅H₁₂N₂O₂	Low Risk - Synonyms
5,5-diphenylimidazolidine-2,4-dione

Primaquine	Antimalarials
C₁₅H₂₁N₃O	High Risk - Synonyms
N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine

Probenecid	Analgesics / Antipyretics
C₁₃H₁₉NO₄S	High Risk - Synonyms
4-[(dipropylamino)sulfonyl] benzoic acid

Procainamide	Cardiovascular Drugs
C₁₃H₂₁N₃O	Low Risk - Synonyms
4-amino-N-(2-diethylaminoethyl)benzamide

Proguanil	Antimalarial
C₁₁H₁₆ClN₅	Low Risk - Synonyms
1-(4-chlorophenyl)-2-(N'-propan-2-ylcarbamimidoyl)guanidine

Pyrimethamine	Antimalarials
C₁₂H₁₃ClN₄	Low Risk - Synonyms
5-(4-chlorophenyl)-6-ethyl-pyrimidine-2,4-diamine

Quinacrine	Antimalarials
C₂₃H_3OClN₃ O	High Risk - Synonyms
N'-(6-chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4 -diamine

Quinidine	Antiarrhythmic Agents / Antimalarials
C₂₀H₂₄N₂O₂	Low Risk - Synonyms
(2-ethenyl-4-azabicyclo[2.2.2]oct-5-yl)-(6-methoxyquinolin-4 -yl)-methanol

Quinine	Antimalarials
C₂₀H₂₄N₂O₂	Low Risk - Synonyms
(2-ethenyl-4-azabicyclo[2.2.2]oct-5-yl)-(6-methoxyquinolin-4 -yl)-methanol

Stibophen	Miscellaneous
C₁₂H₄Na₅O₁₆S₄Sb	High Risk - Synonyms
2-(2-Oxido-3,5-Disulphonatophenoxy)-1,3,2,Benzodioxastibole- 4-6-Disulphonate

Streptomycin	Anti-bacterial
C₂₁H₃₉N₇O₁₂	Low Risk - Synonyms
5-(2,4-diguanidino-3,5,6-trihydroxy-cyclohexoxy)-4-[4,5-dihy droxy-6-(hydroxymethyl)-3-methylamino-tetrahydropyran-2-yl]o xy-3-hydroxy-2-methyl-tetrahydrofuran-3-carbaldehyde

Sulfacetamide	Sulfonamides / Sulfones
C₈H₁₀N₂O₃S	High Risk - Synonyms
N-acetyl-4-amino-benzenesulfonamide

Sulfacytine	Sulfonamides / Sulfones
C₁₂H₁₄N₄O₃S	Low Risk - Synonyms
4-amino-N-(6-methoxy-2-methylpyrimidin-4-yl)benzenesulfonami de

Sulfadiazine	Sulfonamides / Sulfones
C₁₀H₁₀N₄O₂S	Low Risk - Synonyms
4-amino-N-pyrimidin-2-yl-benzenesulfonamide

Sulfadimidine	Sulfonamides / Sulfones
C₁₂H₁₄N₄O₂S	High Risk - Synonyms
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide

Sulfafurazole	Sulfonamides / Sulfones
C₁₁H₁₃N₃O₃S	High Risk - Synonyms
4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide

Sulfaguanidine	Miscellaneous
C₇H₁₀N₄O₂S	Low Risk - Synonyms
4-Amino-N-(diaminomethylene)benzenesulfon Amide

Sulfamerazine	Sulfonamides / Sulfones
C₁₁H₁₂N₄O₂S	Low Risk - Synonyms
4-amino-N-(4-methylpyrimidin-2-yl)benzenesulfonamide

Sulfamethoxazole	Sulfonamides / Sulfones
C₁₀H₁₁N₃O₃S	High Risk - Synonyms
4-amino-N-(5-methyloxazol-3-yl)-benzenesulfonamide

Sulfamethoxypyridazine	Sulfonamides / Sulfones
C₁₁H₁₂N₄O₃S	Low Risk - Synonyms
4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide

Sulfanilamide	Chemotherapeutic
C₆H₈N₂O₂S	High Risk - Synonyms
4-aminobenzenesulfonamide

Sulfapyridine	Sulfonamides / Sulfones
C₁₁H₁₁N₃O₂S	High Risk - Synonyms
4-amino-N-pyridin-2-ylbenzenesulfonamide

Sulfasalazine	Sulfonamides / Sulfones
C₁₈H₁₄N₄O₅S	High Risk - Synonyms
2-hydroxy-5-[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl-benzoi c acid

Sulfathiazole	Cytotoxic / Antibacterial
C₉H₉N₃O₂S₂	High Risk - Synonyms
4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide

Sulfonylurea	Antidiabetic Agents
C₂₁H₂₇N₅O₄S	Low Risk - Synonyms
1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phe nyl] sulfonyl]urea

Sulfoxone	Antibacterial
C₁₄H₁₆N₂O₆S₃	High Risk - Synonyms
[4-[4-(sulfinomethylamino)phenyl]sulfonylphenyl]aminomethane sulfinic acid

Tamsulosin	Sulfonamides
C₂₀H₂₈N₂O₅S	High Risk - Synonyms
5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzen esulfonamide

Tiaprofenic Acid	Anti Inflammatory
C₁₄H₁₂O₃S	Low Risk - Synonyms
2-[5-(benzoyl)thiophen-2-yl]propanoic acid

Toluidine Blue	Miscellaneous
C₁₅H₁₆N₃SCl	High Risk - Synonyms
3-Amino-7-(dimethylamino)-2-methylphenothiazin-5-ium Chloride

Trihexyphenidyl	Antiparkinson Agents
C₂₀H₃₁NO	Low Risk - Synonyms
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol

Trimethoprim	Antimalarials / Antibacterial
C₁₄H₁₈N₄O₃	Low Risk - Synonyms
5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Trinitrotoluene	Miscellaneous
C₇H₅N₃O₆	High Risk - Synonyms
2-methyl-1,3,5-trinitrobenzene

Tripelennamine	Antihistaminic
C₁₆H₂₁N₃	Low Risk - Synonyms
N-benzyl-N',N'-dimethyl-N-pyridin-2-yl-ethane-1,2-diamine

Vitamin K1	Miscellaneous
C₃₁H₄₆O₂	Low Risk - Synonyms
Phytomenadione

Other Substances

Products containing Naphtha, moth balls, sulfites

References:

1. Philippine Pharmaceutical Directory Review 5th Edition. Jocelyn J. Yambao et al. Ed. Medicom Pacific Inc. 2005.

2. MIMS Philippines. Volume 31, Number 3, 2002. Medi Media. 2002.

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