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Recognizing Hemolysis Signs in G6PD Deficiency


Red blood cells carry oxygen to all parts of the body. When they undergo hemolysis, or die, the person will have hemolytic anemia. Visit our overview page for a discussion of G6PD Deficiency. The signs and symptoms of hemolytic anemia are:

  • abnormal paleness or lack of color of the skin or underside of eyelids
    Paleness under the eyelids due to severe anemia Paleness under the eyelids due to severe anemia
  • grayish-blue coloring to fingernails or tongue
    Gray nails due to severe anemia
  • jaundice, or yellowing of the skin, eyes, and mouth
  • fever
  • dizziness
  • confusion
  • headache
  • weakness
  • intolerance of physical activity
  • difficulty breathing
  • tea-colored urine
  • rapid or strong heart beats (tachycardia)
  • heart murmur
  • abdominal or back pain or both

Hemolytic anemia, when very severe, can end in death. Destroyed red blood cells are brought to the liver to be broken down to smaller pieces for disposal. One of the end products of this process is bilirubin, a yellowish substance that accumulates in different parts of the body when too much of it is produced. Quite often, bilirubin accumulates in the skin and causes it to appear yellowish. In the worst cases, bilirubin accumulates in the brain and causes mental retardation or death.

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